|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-aminomethyl-4,5-dihydro-1,3-thiazole-4-carboxyl-[ClbJ_non-ribosomal_peptide_synthase] + aminomalonyl-[ClbK_polyketide_synthase] + NADP+ <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-aminomethyl-1,3-thiazole-4-carboxy-glycyl-[ClbK_polyketide_synthase] + holo_[ClbJ_non-ribosomal_peptide_synthase] + CO2 + NADPH + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21126
|
|
|
|
myristoyl-CoA + L-asparaginyl-[ClbN_polyketide_synthase] <=> myristoyl-D-asparaginyl-[ClbN_polyketide_synthase] + CoA + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21109
|
|
|
|
precolibactin_16b + H2O + H+ <=> colibactin + NH3
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21101
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-glycyl-[ClbJ_non-ribosomal_peptide_synthase] + L-cysteinyl-[ClbJ_non-ribosomal_peptide_synthase] <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-aminomethyl-4,5-dihydro-1,3-thiazole-4-carboxyl-[ClbJ_non-ribosomal_peptide_synthase] + holo_[ClbJ_non-ribosomal_peptide_synthase] + H2O + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21120
|
|
|
|
(glycyl)adenylate + holo_[ClbJ_non-ribosomal_peptide_synthase] <=> glycyl-[ClbJ_non-ribosomal_peptide_synthase] + AMP + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21117
|
|
|
|
L-3-oxoalanyl-[L-seryl-carrier_protein] + H2O + FAD <=> aminomalonyl-[L-seryl-carrier_protein] + FADH2
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21124
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetate + myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-aminomethyl-1,3-thiazole-4-carboxy-2-(aminomethyl)-1,3-thiazole-4-carboxyl-glycyl-[ClbO_polyketide_synthase] + H+ <=> precolibactin_1491 + CO2 + holo_[ClbO_polyketide_synthase]
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21131
|
|
|
|
(L-alanyl)adenylate + holo_[ClbB_polyketide_synthase] <=> L-alanyl-[ClbB_polyketide_synthase] + AMP + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21106
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-glycyl-[ClbJ_non-ribosomal_peptide_synthase] + H2O <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-glycine + holo_[ClbJ_non-ribosomal_peptide_synthase] + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21121
|
|
|
|
myristoyl-D-asparaginyl-[ClbN_polyketide_synthase] + L-alanyl-[ClbB_polyketide_synthase] <=> myristoyl-D-asparaginyl-L-alanyl-[ClbB_polyketide_synthase] + holo_[ClbN_polyketide_synthase] + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21107
|
|
|
|
L-alanine + ATP + H+ <=> (L-alanyl)adenylate + diphosphate
|
not assigned
|
–
|
| |
MetaCyc:
RXN-17190
|
|
|
|
holo-[L-seryl-carrier_protein] + (L-seryl)adenylate <=> L-seryl-[L-seryl-carrier_protein] + AMP + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-16905
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-[ClbI_polyketide_synthase] + glycyl-[ClbJ_non-ribosomal_peptide_synthase] <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-glycyl-[ClbJ_non-ribosomal_peptide_synthase] + holo_[ClbI_polyketide_synthase]
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21119
|
|
|
|
(L-cysteinyl)adenylate + holo_[ClbK_polyketide_synthase] <=> L-cysteinyl-[ClbK_polyketide_synthase] + AMP + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21127
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-aminomethyl-1,3-thiazole-4-carboxy-2-(aminomethyl)-1,3-thiazole-4-carboxyl-[ClbK_polyketide_synthase] + aminomalonyl-[ClbO_polyketide_synthase] <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-aminomethyl-1,3-thiazole-4-carboxy-2-(aminomethyl)-1,3-thiazole-4-carboxyl-glycyl-[ClbO_polyketide_synthase] + holo_[ClbK_polyketide_synthase] + CO2
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21130
|
|
|
|
glycine + ATP <=> (glycyl)adenylate + diphosphate
|
not assigned
|
–
|
| |
MetaCyc:
RXN-9376
SABIO-RK:
13188
|
|
|
|
[ClbG_aminomalonyltransferase]-aminomalonyl-L-serine + holo_[ClbO_polyketide_synthase] <=> aminomalonyl-[ClbO_polyketide_synthase] + [ClbG_aminomalonyltransferase]-L-serine
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21129
|
|
|
|
precolibactin_1491 + H2O <=> unstable_precolibactin_intermediate + N-myristoyl-D-asparagine
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21152
|
|
|
|
L-cysteine + ATP + H+ <=> (L-cysteinyl)adenylate + diphosphate
|
not assigned
|
–
|
| |
MetaCyc:
RXN-11115
|
|
|
|
precolibactin_1491 + Na+ <=> precolibactin_1491 + Na+
|
not assigned
|
–
|
| |
MetaCyc:
TRANS-RXN-393
|
|
|
|
S-adenosyl-L-methionine + ATP + H+ <=> (S-adenosyl-L-methionyl)adenylate + diphosphate
|
2.7.7
|
–
|
| |
MetaCyc:
RXN-21110
|
|
|
|
unstable_precolibactin_intermediate <=> precolibactin_16a + H2O + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21153
|
|
|
|
malonyl-CoA + myristoyl-D-asparaginyl-L-alanyl-[ClbB_polyketide_synthase] + NADPH + H+ <=> myristoyl-D-asparaginyl-butan-2-aminyl-acetyl-[ClbB_polyketide_synthase] + CoA + CO2 + H2O + NADP+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21108
|
|
|
|
precolibactin_16a + acceptor <=> precolibactin_16b + reduced_acceptor + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21102
|
|
|
|
L-asparagine + ATP + H+ <=> (L-asparaginyl)adenylate + diphosphate
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21104
|
|
|
|
holo_[ClbC_polyketide_synthase] + myristoyl-D-asparaginyl-butan-2-aminyl-acetyl-[ClbB_polyketide_synthase] + malonyl-CoA + H+ <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-[ClbC_polyketide_synthase] + holo_[ClbB_polyketide_synthase] + CO2 + CoA
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21114
|
|
|
|
[ClbG_aminomalonyltransferase]-aminomalonyl-L-serine + holo_[ClbK_polyketide_synthase] <=> aminomalonyl-[ClbK_polyketide_synthase] + [ClbG_aminomalonyltransferase]-L-serine
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21125
|
|
|
|
L-serine + ATP + H+ <=> (L-seryl)adenylate + diphosphate
|
not assigned
|
–
|
| |
MetaCyc:
ENTF-RXN
SABIO-RK:
981
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-aminomethyl-1,3-thiazole-4-carboxy-glycyl-[ClbK_polyketide_synthase] + L-cysteinyl-[ClbK_polyketide_synthase] + NADP+ <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-aminomethyl-1,3-thiazole-4-carboxy-2-(aminomethyl)-1,3-thiazole-4-carboxyl-[ClbK_polyketide_synthase] + holo_[ClbK_polyketide_synthase] + H2O + NADPH + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21128
|
|
|
|
aminomalonyl-[L-seryl-carrier_protein] + [ClbG_aminomalonyltransferase]-L-serine <=> [ClbG_aminomalonyltransferase]-aminomalonyl-L-serine + holo-[L-seryl-carrier_protein]
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21151
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-glycine + H2O <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetate + glycine
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21122
|
|
|
|
(L-asparaginyl)adenylate + holo_[ClbN_polyketide_synthase] <=> L-asparaginyl-[ClbN_polyketide_synthase] + AMP + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21105
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-SAM-[ClbH_non-ribosomal_peptide_synthase] <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-[ClbH_non-ribosomal_peptide_synthase] + S-methyl-5''-thioadenosine + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21115
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-[ClbC_polyketide_synthase] + S-adenosyl-L-methionyl-[ClbH_non-ribosomal_peptide_synthase] <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-SAM-[ClbH_non-ribosomal_peptide_synthase] + holo_[ClbB_polyketide_synthase] + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21112
|
|
|
|
L-seryl-[L-seryl-carrier_protein] + NAD+ <=> L-3-oxoalanyl-[L-seryl-carrier_protein] + NADH + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21123
|
|
|
|
(L-cysteinyl)adenylate + holo_[ClbJ_non-ribosomal_peptide_synthase] <=> L-cysteinyl-[ClbJ_non-ribosomal_peptide_synthase] + AMP + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21118
|
|
|
|
myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-[ClbH_non-ribosomal_peptide_synthase] + malonyl-CoA + holo_[ClbI_polyketide_synthase] + H+ <=> myristoyl-D-asparaginyl-butan-2-aminyl-malonyl-1-aminocyclopropane-1-carboxyl-acetyl-[ClbI_polyketide_synthase] + holo_[ClbH_non-ribosomal_peptide_synthase] + CO2 + CoA
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21116
|
|
|
|
(S-adenosyl-L-methionyl)adenylate + holo_[ClbH_non-ribosomal_peptide_synthase] <=> S-adenosyl-L-methionyl-[ClbH_non-ribosomal_peptide_synthase] + AMP + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-21111
|
|
